Medical Marijuana Cannabis Treatment German University Study: Pain, Spasticity, Nausea Redution and Improved Appetite

Clinical Studies and Case Report with cannabis or single cannabinoids Treatment and case reports on the use of cannabis by patients.

A scientist of ay reported of experiences from the treatment of 13 children with severe disabilities and spasticity aged 7 months to 17 years as well as of about 50 cancer patients aged three months and older.

Title	[Cannabinoids in children] [Article in German] Cannabinoide bei Kindern.
Author(s)	Gottschling S.
Journal, Volume, Issue	Angewandte Schmerztherapie und Palliativmedizin 2011;(1):55-57.
Major outcome(s)	Reduced pain, spasticity and improved appetite and nausea reduction
Indication	Appetite loss/weight loss;Cancer;Nausea/vomiting;Pain;Spasticity	Abstract
Medication	Delta-9-THC	From the IACM Bulletin: According to case reports of the Centre for Palliative Medicine and Paediatric Pain Therapy of the University of the Saarland (Germany) THC (dronabinol) is an effective and well-tolerated medicinal drug in the treatment of different severe illnesses in children. A scientist of a university reported of experiences from the treatment of 13 children with severe disabilities and spasticity aged 7 months to 17 years as well as of about 50 cancer patients aged three months and older. All children received a slowly increased dose. Mean dronabinol dose was 0.2 mg/kg bodyweight in children with spasticity and pain after finishing dose finding. In all children a reduction in pain, which was considerable in some of them, was observed within 48 hours after start of treatment. Efficacy with regard to spasticity set in within one to two weeks. In some patients opioid treatment could be reduced. Most cancer patients profited from an increase in appetite and weight, reduction of nausea and vomiting, as well as improved sleep and reduced anxiety. Even with long-term treatment no relevant side-effects were noted.
Route(s)	Oral
Dose(s)	0.2 mg/kg
Duration (days)
Participants	13 children with severe spasticity and 50 children with canc
Design	Uncontrolled case report
Type of publication	Medical journal
Address of author(s)	Universitätsklinikum des Saarlandes, 66421 Homburg, Germany, E-Mail: sven.gottschling@uks.eu
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Medical Marijuana Cancer Treatment: Brain Tumour Spontaneous Regression After Cannabis Inhalation

Clinical Studies and Case Report with cannabis or single cannabinoids Treatment in cancer disease and case reports on the use of cannabis by patients.


Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas-possible role of Cannabis inhalation.

Title
Author(s)	Foroughi M, Hendson G, Sargent MA, Steinbok P.
Journal, Volume, Issue	Childs Nerv Syst. 2011 Apr;27(4):671-9.
Major outcome(s)	Spontaneous regression of benign brain tumour may have been associated with cannabis use.
Indication	Cancer	Abstract
Medication	Cannabis	INTRODUCTION: Spontaneous regression of pilocytic astrocytoma after incomplete resection is well recognized, especially for cerebellar and optic pathway tumors, and tumors associated with Neurofibromatosis type-1 (NF1). The purpose of this report is to document spontaneous regression of pilocytic astrocytomas of the septum pellucidum and to discuss the possible role of cannabis in promoting regression. CASE REPORT: We report two children with septum pellucidum/forniceal pilocytic astrocytoma (PA) tumors in the absence of NF-1, who underwent craniotomy and subtotal excision, leaving behind a small residual in each case. During Magnetic Resonance Imaging (MRI) surveillance in the first three years, one case was dormant and the other showed slight increase in size, followed by clear regression of both residual tumors over the following 3-year period. Neither patient received any conventional adjuvant treatment. The tumors regressed over the same period of time that cannabis was consumed via inhalation, raising the possibility that the cannabis played a role in the tumor regression. CONCLUSION: We advise caution against instituting adjuvant therapy or further aggressive surgery for small residual PAs, especially in eloquent locations, even if there appears to be slight progression, since regression may occur later. Further research may be appropriate to elucidate the increasingly recognized effect of cannabis/cannabinoids on gliomas.
Route(s)	Inhalation
Dose(s)
Duration (days)
Participants	2 patients with pilocytic astrocytoma
Design	Uncontrolled case report
Type of publication	Medical journal
Address of author(s)	Division of Pediatric Neurosurgery, Department of Surgery, BC Children's Hospital, 4480 Oak Street, Vancouver, BC, Canada, V6H 3V4.